Senior Director, Head of Mechanistic Pharmacology

Company: Disability Solutions
Location: Spring House
Posted on: October 5, 2024

Job Description:

Johnson & Johnson is recruiting for a Senior Director, Head of Mechanistic Pharmacology, located in Spring House, PA.Our Discovery Technology and Molecular Pharmacology (DTMP) organization is looking for a Senior Director, Head of Mechanistic Pharmacology. This Senior Scientific Director will report into our Vice President DTMP and lead a core function located at our two research sites including Spring House, PA and Lo Jolla, CA. The incumbent will lead a state-of-the-art cellular screening capability with a special emphasis on the development and application of high throughput screening assays to support all TAs from portfolio entries to NME transition. This includes resource allocation and priority alignment. In addition, their team will be responsible for mechanistic pharmacology assay development and platform execution to drive high throughput in-vitro mechanistic pharmacology data generation and address IVIVC needs using high throughput translational assay platform and scalable complex cellular models. Receptor pharmacology and translational pharmacology will be the core expertise for this team.The incumbent will work closely with the DTMP senior leadership team to set the strategic direction for this core function, establish robust end-to-end processes and build high throughput cellular pharmacology assays across Discovery pipeline using technology innovation across multimodalities including small molecules, cell therapy, biologics, and RNA therapeutics. The incumbent will collaborate with the preclinical science and translational safety team to develop the translational pharmacology strategy and execute early safety risk assessment assays through technology innovation and lab automation to enhance therapeutic quality and incorporate the execution plans into our therapeutic transition packages. In addition, the incumbent will regularly interact with the leaders across Therapeutic Discovery to provide appropriate insights and expert diligence on promising opportunities in the external innovation environment. The incumbent will lead the team to launch phenotypic screening strategy, drive our cellular technology/Biosignature platforms and deliver transition data to enable AIML model development and execution.\rMajor Duties & Responsibilities include but are not limited to:

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• Coordinate project needs and timeline and deliverables and resource distribution across portfolio and across sites
• Address PPI and complex target capability and cellular target engagement
• Drive important initiatives together with TD Modality leaders, TA leaders and DTMP leaders
• Lead Innovation, drive functional efficiency to impact drug design, target ID, target engagement and tool molecule ID/hypothesis validation
• Develop and execute partnerships with leaders across Janssen\r\r

Keywords: Disability Solutions, Reading , Senior Director, Head of Mechanistic Pharmacology, Executive , Spring House, Pennsylvania